Biocontainment in Gain-of-Function Infectious Disease Research
نویسندگان
چکیده
منابع مشابه
Biocontainment in Gain-of-Function Infectious Disease Research
The discussion of H5N1 influenza virus gain-of-function research has focused chiefly on its risk-to-benefit ratio. Another key component of risk is the level of containment employed. Work is more expensive and less efficient when pursued at biosafety level 4 (BSL-4) than at BSL-3 or at BSL-3 as modified for work with agricultural pathogens (BSL-3-Ag). However, here too a risk-to-benefit ratio a...
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15 صفحه اولWhen gain-of-function research is not "gain-of-function" research.
T here is ongoing discussion among the scientific and biosecurity communities over how to address concerns about “gain-of-function” (GOF) research using highly pathogenic agents [1–3]. The discussion has mainly centered on previous work by Yoshihiro Kawaoka’s group at the University of Madison-Wisconsin in the USA [4] and Ron Fouchier’s group at Rotterdam University in the Netherlands [5]. Both...
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Understanding interactions between animals and humans is critical in preventing outbreaks of zoonotic disease. This is particularly important for avian influenza. Food animal production has been transformed since the 1918 influenza pandemic. Poultry and swine production have changed from small-scale methods to industrial-scale operations. There is substantial evidence of pathogen movement betwe...
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ژورنال
عنوان ژورنال: mBio
سال: 2012
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00290-12